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A new efficient method for one‐pot conversions of aryl carboxylic acids into nitriles without solvent
Author(s) -
Cao YuQing,
Zhang Zhan,
Guo YanXin
Publication year - 2008
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.1961
Subject(s) - thionyl chloride , chemistry , reagent , aryl , organic chemistry , yield (engineering) , solvent , dehydration , environmental pollution , carbamate , chloride , combinatorial chemistry , alkyl , materials science , biochemistry , environmental protection , environmental science , metallurgy
A new efficient method for synthesising nitriles, important organic reagents, is reported in this paper. In an environmentally benign solvent‐free system, aryl carboxylic acids were converted into the corresponding nitriles via one‐pot reactions, by amidation with ethyl carbamate followed by dehydration with thionyl chloride, in excellent yields. The results showed that the method has the advantages of lower cost, higher yield, less pollution and greater ease of work‐up. Copyright © 2008 Society of Chemical Industry