Premium
Biotransformation of isoflavones by Aspergillus niger as biocatalyst
Author(s) -
Miyazawa Mitsuo,
Takahashi Koji,
Araki Hideo
Publication year - 2006
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.1461
Subject(s) - aspergillus niger , biotransformation , isoflavones , regioselectivity , biocatalysis , chemistry , aspergillus , stereochemistry , organic chemistry , enzyme , biochemistry , botany , biology , catalysis , reaction mechanism
Abstract Biotransformation of the isoflavones, 6,7,4′‐trimethoxyisoflavone ( 1 ) and 5,7,4′‐trimethoxyisoflavone ( 2 ) by Aspergillus niger was investigated. Compound 1 was transformed to 4′‐hydroxy‐6,7‐dimethoxyisoflavone ( 3 ) and 2 to 4′‐hydroxy‐5,7‐dimethoxyisoflavone ( 4 ). This suggested that 1 and 2 were demethylated at the C‐4′ position with regioselectivity by Aspergillus niger . Copyright © 2006 Society of Chemical Industry