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Phenoxymethylpenicillin–intercalated hydrotalcite as a bacteria inhibitor
Author(s) -
Li WenZhuo,
Lu Jun,
Chen JieSheng,
Li GuoDong,
Jiang YuSheng,
Li LianSheng,
Huang BaiQu
Publication year - 2006
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.1362
Subject(s) - hydrotalcite , molecule , intercalation (chemistry) , composite number , hydroxide , bacteria , layered double hydroxides , chemical engineering , drug , materials science , chemistry , nuclear chemistry , combinatorial chemistry , nanotechnology , organic chemistry , pharmacology , medicine , catalysis , composite material , biology , engineering , genetics
Phenoxymethylpenicillin (PMP) has been reversibly intercalated into a layered double hydroxide, and the resulting composite exhibits effective anti‐bacterial activity. Powder X‐ray diffraction studies indicate that the PMP molecules are interdigitated between the inorganic layers, and under mild acidic media, the molecules are released gradually. Therefore a sustained‐release anti‐bacterial medication is envisioned on the basis of this inorganic–drug composite. Copyright © 2005 Society of Chemical Industry