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Synthesis and characterization of a synthetic heme‐based oxygen carrier
Author(s) -
AlKassim Loola,
Wang Z,
Szabo Arthur G,
Taylor Keith E,
Mutus Bulent
Publication year - 2005
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.1279
Subject(s) - oxygen , dendrimer , stoichiometry , imidazole , chemistry , hematoporphyrin , succinic acid , spectroscopy , clark electrode , heme , nuclear chemistry , inorganic chemistry , stereochemistry , polymer chemistry , electrode , organic chemistry , photodynamic therapy , physics , quantum mechanics , electrolyte , enzyme
We have prepared a novel oxygen carrier composed of Starburst dendrimer 3 hematoporphyrin iron(III) di‐1‐(3‐aminopropyl)imidazole di‐succinic acid (SDHAPI). This compound has a molecular weight of ∼12.7 kD. O 2 and CO binding to SDHAPI was demonstrated by UV‐vis spectroscopy. Oxygenated SDHAPI had an estimated auto‐oxidation half‐life of 24 min. The oxygen stoichiometry (∼6 mol of O 2 mol −1 SDHAPI) and the k obs(on+off) of 0.084 s −1 and k obs(off) of 0.009 s −1 were estimated with an oxygen electrode. Copyright © 2005 Society of Chemical Industry