Synthesis and characterization of a synthetic heme‐based oxygen carrier | Zendy

AlKassim Loola | Zendy; Wang Z | Zendy; Szabo Arthur G | Zendy; Taylor Keith E | Zendy; Mutus Bulent | Zendy

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Synthesis and characterization of a synthetic heme‐based oxygen carrier

Author(s) -

AlKassim Loola,

Wang Z,

Szabo Arthur G,

Taylor Keith E,

Mutus Bulent

Publication year - 2005

Publication title -

journal of chemical technology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.64

H-Index - 117

eISSN - 1097-4660

pISSN - 0268-2575

DOI - 10.1002/jctb.1279

Subject(s) - oxygen , dendrimer , stoichiometry , imidazole , chemistry , hematoporphyrin , succinic acid , spectroscopy , clark electrode , heme , nuclear chemistry , inorganic chemistry , stereochemistry , polymer chemistry , electrode , organic chemistry , photodynamic therapy , physics , quantum mechanics , electrolyte , enzyme

We have prepared a novel oxygen carrier composed of Starburst dendrimer 3 hematoporphyrin iron(III) di‐1‐(3‐aminopropyl)imidazole di‐succinic acid (SDHAPI). This compound has a molecular weight of ∼12.7 kD. O 2 and CO binding to SDHAPI was demonstrated by UV‐vis spectroscopy. Oxygenated SDHAPI had an estimated auto‐oxidation half‐life of 24 min. The oxygen stoichiometry (∼6 mol of O 2 mol −1 SDHAPI) and the k obs(on+off) of 0.084 s −1 and k obs(off) of 0.009 s −1 were estimated with an oxygen electrode. Copyright © 2005 Society of Chemical Industry

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