Premium
Analysis of acetic acid productivity in a continuous two‐stage bioreactor with cell recycling
Author(s) -
Nishiwaki Akio,
Dunn Irving J
Publication year - 2005
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.1207
Subject(s) - industrial fermentation , acetic acid , bioreactor , chemostat , bleed , substrate (aquarium) , stage (stratigraphy) , chemistry , productivity , pulp and paper industry , chromatography , fermentation , food science , biochemistry , biology , organic chemistry , engineering , bacteria , art , ecology , paleontology , macroeconomics , economics , visual arts , genetics
The performance of a two‐stage system with cell recycling and fresh feed at each stage is studied numerically for continuous acetic acid production. In this system, both filtrate and bleed broth from the first stage are supplied to the second fermenter. At high substrate conversions, this configuration is found to provide higher acetic acid productivities than either a previous configuration where only the first‐stage bleed broth is fed to the second stage or a single recycle chemostat at the same bleed ratios. Copyright © 2005 Society of Chemical Industry