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The antifungal activity and biotransformation of diisophorone by the fungus Aspergillus niger
Author(s) -
Kiran Ismail,
Yildirim Hande N,
Hanson James R,
Hitchcock Peter B
Publication year - 2004
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/jctb.1130
Subject(s) - aspergillus niger , biotransformation , antifungal , fungus , microbiology and biotechnology , aspergillus , traditional medicine , chemistry , biology , medicine , biochemistry , botany , enzyme
Abstract The microbial transformation of racemic diisophorone was investigated using the plant pathogen Aspergillus niger as a biocatalyst. Incubation of diisophorone with Aspergillus niger gave 8α‐hydroxy‐diisophorone, 10‐hydroxydiisophorone and 17‐hydroxydiisophorone on the basis of their spectroscopic data including two‐dimensional NMR analysis, nOe and an X‐ray crystallographic study. The antifungal activity of diisophorone against Aspergillus niger was also examined. Copyright © 2004 Society of Chemical Industry