Open AccessCachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective
Author(s) -
Sanders Karin J. C.,
Kneppers Anita E. M.,
Bool Coby,
Langen Ramon C. J.,
Schols Annemie M. W. J.
Publication year - 2016
Publication title -
journal of cachexia, sarcopenia and muscle
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.803
H-Index - 66
eISSN - 2190-6009
pISSN - 2190-5991
DOI - 10.1002/jcsm.12062
Subject(s) - cachexia , wasting , copd , medicine , pulmonary disease , intensive care medicine , disease , wasting syndrome , pathophysiology , bioinformatics , cancer , biology
Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD‐induced cachexia.