Premium
Effect of Disease Pathologies on Transporter Expression and Function
Author(s) -
AtilanoRoque Amandla,
Roda Gavriel,
Fogueri Uma,
Kiser Jennifer J.,
Joy Melanie S.
Publication year - 2016
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.768
Subject(s) - transporter , disease , drug , pharmacology , efflux , organic anion transporter 1 , biology , medicine , liver disease , biochemistry , gene
Transporters are important determinants of drug absorption, distribution, and excretion. The clinical relevance of drug transporters in drug disposition and toxicology depends on their localization in liver, kidney, and brain. There has been growing evidence regarding the importance of disease status on alterations in metabolizing enzymes and transporter proteins. This review focuses on uptake and efflux transporter proteins in liver, kidney, and brain and discusses mechanisms of altered transporter expression and function secondary to disease.