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Race‐Specific Pharmacodynamic Model of Propofol‐Induced Loss of Consciousness
Author(s) -
Lampotang Samsun,
Lizdas David E.,
Derendorf Hartmut,
Gravenstein Nikolaus,
Lok Benjamin,
Quarles John P.
Publication year - 2016
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.716
Subject(s) - propofol , pharmacodynamics , race (biology) , consciousness , medicine , anesthesia , pharmacokinetics , pharmacology , psychology , biology , neuroscience , botany
Abstract We present a race‐specific model of propofol‐induced loss of consciousness that is based on pharmacodynamic data collected and adapted from the peer‐reviewed literature. In the proposed race‐specific model that includes EC05 and EC95 concentrations, the median (EC50) (and where available 95%CI) propofol concentrations at the effect site compartment for propofol‐induced loss of consciousness for whites, Chinese, blacks, and Indians are 2.8 (2.7‐2.9), 2.2 (2.2‐2.3), 2.0, and 1.9 μg/mL, respectively.