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A Population Pharmacokinetic/Pharmacodynamic Model Predicts Favorable HDL Cholesterol Changes Over the First 5 Years in Children Treated With Current Efavirenz‐Based Regimens
Author(s) -
Homkham tiya,
Cressey Tim R.,
Ingsrisawang Lily,
Bouazza Naïm,
Ngampiyaskul Chaiwat,
Hongsiriwon Suchat,
Srirojana Sakulrat,
Kanjanavanit Suparat,
Bhakeecheep Sorakij,
Coeur Sophie Le,
Salvadori Nicolas,
Treluyer Jean Marc,
Jourdain Gonzague,
Urien Saik
Publication year - 2016
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.701
Subject(s) - efavirenz , pharmacokinetics , pharmacodynamics , cholesterol , interquartile range , dosing , population , pharmacology , endocrinology , medicine , body mass index , chemistry , antiretroviral therapy , human immunodeficiency virus (hiv) , immunology , environmental health , viral load
Efavirenz use is associated with changes in cholesterol concentrations, but it is unclear whether this effect is related to drug concentrations. Using efavirenz and cholesterol plasma concentrations measured in 87 antiretroviral‐naive children in Thailand, we assessed indirect response models to describe the evolution of high‐ and low‐density lipoprotein (HDL, LDL) cholesterol concentrations in relation to efavirenz plasma concentrations over time where efavirenz was assumed to either stimulate cholesterol production or inhibit its elimination. Simulations of cholesterol evolution for children with different average efavirenz concentrations (C av ) according to their assumed status of “fast” or “slow” metabolizers of efavirenz were performed. At treatment initiation, children's median (interquartile range, IQR) age was 8 years (5 to 10), body mass index z‐score 0.01 (–1.05 to 1.44), HDL 31 mg/dL (24 to 44), and LDL 83 mg/dL (69 to 100). Median (IQR) efavirenz C av was 1.7 mg/L (1.3 to 2.1) during the period of observation. The best model describing the evolution of HDL and LDL cholesterol concentrations over time assumed that efavirenz inhibited their elimination. HDL concentrations increase over 5 years, whereas LDL concentrations increased only during the first 4 months and then returned to baseline levels afterward. Simulations predicted that, after 3 years, HDL would increase to 63 mg/dL in “fast” metabolizers and 97 mg/dL in “slow” metabolizers of efavirenz. The population pharmacokinetic‐pharmacodynamic (PK‐PD) model shows that favorable HDL cholesterol changes can be expected in children with current efavirenz dosing guidelines over 5 years of treatment.