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Propofol‐Interrupted Tinnitus Later Suppressed by Amantadine: A Case‐Report
Author(s) -
Dardennes Roland,
Al Anbar Nebal,
Rouillon Frédéric
Publication year - 2013
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.6
Subject(s) - amantadine , propofol , medicine , anesthesia , tinnitus , pharmacology , audiology
Abstract Tinnitus is a frequent condition without consistently effective remediation. Mr V. was a 64 year old man with Behcet's disease, a generalized systemic relapsing vasculitis. Tinnitus appeared in 1998 and he had been both aware and distressed by his tinnitus 80% of his awake time. After his last colonoscopic examination, he mentioned a transient interruption of his tinnitus. Mr V. only received propofol, an anesthesic drug that selectively down‐regulates glutamatergic synaptic transmission. Amantadine, another glutamate antagonist, was later prescribed and durably suppressed tinnitus. Systematically inquiry about post‐anesthesia effects on tinnitus may help decide if amantadine may be tried on an individual basis.