Premium
Population pharmacokinetic modeling of quetiapine after administration of seroquel and seroquel XR formulations to Western and Chinese patients with schizophrenia, schizoaffective disorder, or bipolar disorder
Author(s) -
Zhou Diansong,
Bui Khanh H.,
Li Jianguo,
AlHuniti Nidal
Publication year - 2015
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.544
Subject(s) - quetiapine , pharmacokinetics , population , schizoaffective disorder , medicine , quetiapine fumarate , volume of distribution , schizophrenia (object oriented programming) , pharmacology , anesthesia , atypical antipsychotic , psychiatry , psychosis , antipsychotic , environmental health
A population model describing quetiapine pharmacokinetics (PK) in Western and Chinese patients following oral administration of immediate‐release (IR) and extended‐release (XR) formulations was developed using plasma concentrations in 127 patients from 5 studies with quetiapine IR and/or XR in Western patients and 1 study with quetiapine XR in Chinese patients. A 1‐compartmental model with first‐order absorption and first‐order elimination adequately described the quetiapine PK. The typical apparent volume of distribution and elimination rate constant of quetiapine were 574 L and 0.12 h − 1 , respectively. The estimated population absorption rate constants were 1.46 and 0.10 h −1 for quetiapine IR and XR, respectively. Covariate analysis revealed that race was not a significant covariate influencing the PK of quetiapine. Simulation conducted with the final quetiapine population PK model predicted that the administration of a 200‐mg twice‐daily dose of quetiapine IR in Chinese patients would achieve a steady‐state AUC (AUC ss ) ± standard deviation of 3087 ± 1480 ng · h/mL, which is in close agreement with the reported value (3538 ± 1728 ng · h/mL). The model also predicted that once‐daily administration of 300 mg quetiapine IR or XR would achieve similar exposure in terms of AUC ss in Chinese patients.