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Effects of the contraceptive skin patch and subdermal contraceptive implant on markers of endothelial cell activation and inflammation
Author(s) -
HernandezJuarez Jesus,
SanchezSerrano Juan Carlos,
MorenoHernandez Manuel,
AlvaradoMoreno Jose Antonio,
HernandezLopez Jose Rubicel,
IsordiaSalas Irma,
MajlufCruz Abraham
Publication year - 2015
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.477
Subject(s) - contraceptive implant , medicine , inflammation , population , research methodology , immunology , family planning , environmental health
Changes in blood coagulation factors may partially explain the association between hormonal contraceptives and thrombosis. Therefore, the likely effects of the contraceptive skin patch and subdermal contraceptive implant on levels of inflammatory markers and endothelial activation were analyzed. This was an observational, prospective, longitudinal, nonrandomized study composed of 80 women between 18 and 35 years of age who made the decision to use the contraceptive skin patch or subdermal contraceptive implant. vascular cell adhesion molecule‐1 (VCAM‐1), endothelial cell leukocyte adhesion molecule‐1 (ELAM‐1), von Willebrand factor (VWF), and plasminogen activator inhibitor type 1(PAI‐1) as well as high‐sensitivity C‐reactive protein (hsCRP) were assayed before and after 4 months of use of the contraceptive method. VCAM‐1, VWF, and PAI‐1 remained unchanged in the contraceptive skin patch group; however, a significant increase in hsCRP (0.29–0.50 mg/dL; P =.012) and a significant decrease in ELAM‐1 (44–25 ng/mL; P =.022) were observed. A significant diminution in VCAM‐1 (463–362 ng/mL; P =.022) was also found in the subdermal contraceptive implant group. Our results strongly suggest that these contraceptive methods do not induce endothelial activation after 4 months of use. Increase in hsCRP levels was unrelated to changes in markers of endothelial activation.