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Absence of an effect of T89 on the steady‐state pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
Author(s) -
Wang Ping,
Sun He,
Yang Liu,
Li LingYan,
Hao Jing,
Ruff Dennis,
Guo ZhiXin
Publication year - 2014
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.209
Subject(s) - warfarin , pharmacodynamics , pharmacokinetics , medicine , confidence interval , cmax , pharmacology , anesthesia , atrial fibrillation
This open‐label, multi‐dose, single‐center, sequential, inpatient study evaluated the effects of a two herb combination drug (T89, Danshen plus Sanqi) on the steady‐state pharmacodynamics (PD) and pharmacokinetics (PK) of warfarin in 24 healthy volunteers. Twenty‐three subjects attained a stable international normalized ratio (INR) by taking warfarin alone prior to 1‐week of added‐on use of T89. INR was not increased after the addition of T89 for 7 days ( P > .05). The 90% confidence interval (CI) of the geometric mean ratio for maximum plasma concentrations (C max ) and area under curve (AUC last ) of both R‐ and S‐warfarin when warfarin was administered with or without T89 was within the 0.80 to 1.25 equivalence ratio. These results indicate that T89 has no effect on the steady‐state PD and PK of warfarin. Warfarin and T89 dose adjustments are not required when these two drugs are co‐administrated in clinical practice.