Premium
A Survey on Knowledge Gaps in Assessment and Management of Severe Drug Hypersensitivity Reactions: Multicenter Cross‐Sectional Study of Australian Health Care Providers
Author(s) -
Mazzoni Daniel,
Tee Hui Wen,
Menezes Sara Lee,
Graudins Linda Velta,
Johnson Douglas Forsyth,
Newnham Evan David,
Kelley Peter Graham,
Zubrinich Celia Mary,
Goh Michelle Sue Yen,
Trubiano Jason Anthony,
Aung Ar Kar
Publication year - 2021
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.1692
Subject(s) - medicine , preparedness , specialty , cross sectional study , family medicine , multidisciplinary approach , attribution , clinical pharmacy , health care , psychology , pharmacy , pathology , social psychology , social science , sociology , political science , law , economics , economic growth
Severe drug hypersensitivity reactions (DHRs) are often encountered by health care professionals (HCPs). We evaluated knowledge of doctors and pharmacists in the assessment and management of severe DHRs using a structured questionnaire. A cross‐sectional study was conducted in 4 metropolitan hospital networks in Melbourne, Australia. A 13‐question, scenario‐based multiple‐choice questionnaire to assess specific knowledge domains in drug hypersensitivity syndrome recognition, causality attribution, cross‐reactivity patterns, appropriate diagnostic tests, and therapy was administered to HCPs of various vocation and specialty groups. Data were analyzed according to profession, self‐reported experience, and preparedness in managing severe DHRs. Two hundred thirty‐eight participants (45.0% senior doctors, 24.4% junior doctors, and 30.7% pharmacists) across a range of subspecialties achieved an overall median score of 7 (IQR, 5‐8)—overall 55.6% correct responses to all questions—with senior doctors outperforming junior doctors and pharmacists ( P < .001). The best performance by all participants was in DHR syndrome recognition (60.9%), and the poorest was in diagnostics/therapy (52.0%). HCP group and experience level were significantly associated with better performance in the knowledge domains of cross‐reactivity and diagnostics/therapy ( P = .003 and < .001, respectively), but not in the domains of syndrome recognition and causality attribution ( P > .05). Levels of self‐reported preparedness in DHR management were not associated with performance rates in any of the knowledge domains. This study demonstrated significant knowledge gaps in the recognition and management of severe drug hypersensitivity reactions. Targeted multidisciplinary education of staff caring for these patients is needed to improve knowledge gaps.