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The Role of Clinical Pharmacology in Chemotherapy of Multidrug‐Resistant Plasmodium falciparum
Author(s) -
Karbwang Juntra,
NaBangchang Kesara
Publication year - 2020
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.1589
Subject(s) - plasmodium falciparum , pharmacology , malaria , pharmacokinetics , multiple drug resistance , pharmacodynamics , medicine , dosing , clinical pharmacology , chemotherapy , drug resistance , biology , immunology , microbiology and biotechnology
Malaria remains one of the major global public health problems due to the emergence and spread of multidrug‐resistant Plasmodium falciparum . In recent years, clinical pharmacology has significantly contributed to the optimal dosing regimens of antimalarial drugs. The application of pharmacometric modeling and simulation has assisted in the accurate characterization of pharmacokinetic‐pharmacodynamic relationships and the optimization of the dosage regimens of existing antimalarial drugs, including new antimalarial candidates for multidrug‐resistant P falciparum in different populations.