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Population Pharmacokinetic Modeling of Mogamulizumab in Adults With Cutaneous T‐Cell Lymphoma or Adult T‐Cell Lymphoma
Author(s) -
Mukai Mayumi,
Maeda Hiroshi,
Narushima Kazuya,
Mould Diane R.,
Greene Douglas
Publication year - 2020
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.1564
Subject(s) - medicine , mycosis fungoides , lymphoma , population , volume of distribution , cutaneous t cell lymphoma , oncology , adult t cell leukemia/lymphoma , immunology , gastroenterology , pharmacokinetics , t cell leukemia , environmental health
Abstract Cutaneous T‐cell lymphoma (CTCL) and adult T‐cell leukemia/lymphoma (ATL) are rare non‐Hodgkin lymphomas commonly expressing C‐C chemokine receptor 4 (CCR4). Mogamulizumab is a humanized monoclonal antibody against CCR4 approved in the United States for the treatment of patients with relapsed/refractory mycosis fungoides or Sézary syndrome, the most common forms of CTCL. Pharmacokinetic (PK) and clinical study data from 444 adult patients with ATL or CTCL collected during 6 clinical trials of mogamulizumab were used to construct a population PK model, which was best described by a 2‐compartment model with linear clearance. Albumin, aspartate aminotransferase, mild‐to‐moderate hepatic impairment, and sex were statistically significant predictors of clearance; albumin was also a statistically significant predictor of peripheral volume of distribution; and body surface area was a statistically significant predictor for central volume of distribution. None of the other covariates—for example, age, body weight, body mass index, bilirubin, creatinine clearance, disease type (ATL and CTCL), ATL subtype (acute, lymphoma, and chronic), CTCL subtype (mycosis fungoides and Sézary syndrome), CCR4 expression (status or degree), race (Japanese and non‐Japanese), renal impairment (normal, mild, moderate, and severe), or performance status—had a statistically significant impact. Performance of the final population PK model was acceptable. This model will be valuable for guiding further studies of mogamulizumab.