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Effects of Ketoconazole, a CYP4F2 Inhibitor, and CYP4F2*3 Genetic Polymorphism on Pharmacokinetics of Vitamin K 1
Author(s) -
Park JinWoo,
Kim KyoungAh,
Park JiYoung
Publication year - 2019
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/jcph.1444
Subject(s) - ketoconazole , pharmacokinetics , vitamin , pharmacology , pharmacogenetics , placebo , medicine , chemistry , genotype , biochemistry , gene , pathology , antifungal , alternative medicine , dermatology
The objective of this study was to evaluate whether cytochrome P450 (CYP)4F2 is involved in the exposure of vitamin K 1 through a drug interaction study with ketoconazole, a CYP4F2 inhibitor, and a pharmacogenetic study with CYP4F2*3 . Twenty‐one participants with different CYP4F2*3 polymorphisms were enrolled (8 for *1/*1 , 7 for *1/*3 , and 6 for *3/*3 ). All participants were treated twice daily for 5 days with 200 mg of ketoconazole or placebo. Finally, a single dose of 10 mg vitamin K 1 was administered, plasma levels of vitamin K 1 were measured, and its pharmacokinetics was assessed. Ketoconazole elevated the plasma levels of vitamin K 1 and increased the average area under the concentration‐time curve (AUC inf ) and peak concentration by 41% and 40%, respectively. CYP4F2*3 polymorphism also affected plasma levels of vitamin K 1 and its pharmacokinetics in a gene dose–dependent manner. The average AUC inf value was 659.8 ng·h/mL for CYP4F2*1/*1 , 878.1 ng·h/mL for CYP4F2*1/*3 , and 1125.2 ng·h/mL for CYP4F2*3/*3 ( P = .010). This study revealed that ketoconazole and CYP4F2*3 polymorphism substantially increased the exposure of vitamin K 1 in humans. These findings provide a plausible explanation for variations in warfarin dose requirements resulting from interindividual variations in vitamin K 1 exposure due to CYP4F2‐related drug interactions and genetic polymorphisms.