Premium
Role of pyroptosis in atherosclerosis and its therapeutic implications
Author(s) -
He Bin,
Nie Qiangqiang,
Wang Feng,
Han Yongxin,
Yang Bo,
Sun Mingsheng,
Fan Xueqiang,
Ye Zhidong,
Liu Peng,
Wen Jianyan
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30366
Subject(s) - pyroptosis , proinflammatory cytokine , medicine , programmed cell death , inflammation , immunology , inflammasome , biology , apoptosis , biochemistry
Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL‐1β and IL‐18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.