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Band 3 protein function and oxidative stress in erythrocytes
Author(s) -
Remigante Alessia,
Morabito Rossana,
Marino Angela
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30322
Subject(s) - band 3 , oxidative stress , cytoskeleton , oxidative phosphorylation , microbiology and biotechnology , red blood cell , transporter , biophysics , cell function , membrane , function (biology) , homeostasis , cell , chemistry , cell membrane , erythrocyte membrane , biochemistry , biology , gene
Abstract Band 3 protein (B3p), anion transporter, allows the HCO 3 − /Cl − exchange across plasma membrane and plays an important role for erythrocytes homeostasis. In addition, B3p is linked to proteins cytoskeleton, thus contributing to cell shape and deformability, essential to erythrocytes adjustment within narrowest capillaries. Taking into account that erythrocytes are a suitable cell model to investigate the response of the oxidative stress effects, B3p functions, and specifically anion exchange capability, determining the rate constant for SO 4 2− uptake, has been considered. As, in the latter years, rising attention has been addressed to membrane transport system, and particularly to this protein, the present mini‐review has been conceived to report the most recent knowledge about B3p, with specific regard to its functions in oxidative stress conditions, including oxidative stress‐related diseases.