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The vital role of Gli1 + mesenchymal stem cells in tissue development and homeostasis
Author(s) -
Jing Dian,
Li Chaoyuan,
Yao Ke,
Xie Xudong,
Wang Peiqi,
Zhao Hu,
Feng Jian Q.,
Zhao Zhihe,
Wu Yafei,
Wang Jun
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30310
Subject(s) - gli1 , mesenchymal stem cell , homeostasis , microbiology and biotechnology , biology , hedgehog , hedgehog signaling pathway , stem cell , signal transduction
The hedgehog (Hh) signaling pathway plays an essential role in both tissue development and homeostasis. Glioma‐associated oncogene homolog 1 (Gli1) is one of the vital transcriptional factors as well as the direct target gene in the Hh signaling pathway. The cells expressing the Gli1 gene (Gli1 + cells) have been identified as mesenchymal stem cells (MSCs) that are responsible for various tissue developments, homeostasis, and injury repair. This review outlines some recent discoveries on the crucial roles of Gli1 + MSCs in the development and homeostasis of varieties of hard and soft tissues.