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CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells
Author(s) -
VegaMendoza Daniela,
CañasLinares Alicia,
FloresAlcantar Angel,
EspinosaNeira Roberto,
MelchyPerez Erika,
VeraEstrella Rosario,
Auvynet Constance,
Rosenstein Yvonne
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30308
Subject(s) - angiogenesis , extracellular matrix , a549 cell , cancer research , tumor microenvironment , biology , microbiology and biotechnology , lung cancer , pathology , medicine , tumor cells
Aberrant expression of CD43 in malignant tumors of nonhematopoietic origin such as those from lung, cervix, colon, and breast has been shown to correlate with poor prognosis, providing tumor cells with enhanced motility, anchorage‐independent growth, and in vivo tumor size, while protecting the cells of NK lysis and apoptosis. To further characterize the role of CD43 in cell transformation, we tested whether interfering its expression modified the capacity of the A549 non‐small cell lung cancer cells to secrete molecules contributing to malignancy. The proteomic analysis of the secretome of serum‐starved A549 cells revealed that cells expressing normal levels of CD43 released significantly high levels of molecules involved in extracellular matrix organization, angiogenesis, platelet degranulation, collagen degradation, and inflammation, as compared to CD43 RNAi cells. This data reveals a novel and unexpected role for CD43 in lung cancer development, mainly in remodeling the tumor microenvironment.