Premium
The role of HDAC11 in obesity‐related metabolic disorders: A critical review
Author(s) -
Yang Hong,
Chen Lingling,
Sun Qian,
Yao Fangyao,
Muhammad Saeed,
Sun Chao
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30286
Subject(s) - histone deacetylase , hdac11 , obesity , biology , function (biology) , bioinformatics , histone , microbiology and biotechnology , endocrinology , genetics , gene
At present, metabolic diseases, such as obesity and diabetes, have become the world's top health threats. These diseases are closely related to the abnormal development and function of adipocytes and metabolic inflammation associated with obesity. Histone deacetylase 11 (HDAC11), with a relatively unique structure and function in the HDAC family, plays a vital role in regulating cell growth, migration, and cell death. Currently, research on new key regulatory functions of HDAC11 in metabolic homeostasis is receiving more and more attention, and HDAC11 has also become a potential therapeutic target in the treatment of obesity and obesity‐related diseases. Here, we summarized the latest literature on the role of HDAC11 in regulating the progress of obesity‐related metabolic disorders.