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Signaling, metabolism, and cancer: An important relationship for therapeutic intervention
Author(s) -
VaghariTabari Mostafa,
Ferns Gordon A.,
Qujeq Durdi,
Andevari Ali Nosrati,
Sabahi Zahra,
Moein Soheila
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30276
Subject(s) - cell metabolism , cancer cell , biology , cancer , metastasis , signal transduction , cell growth , cancer research , apoptosis , cellular metabolism , cell , metabolism , cell signaling , microbiology and biotechnology , bioinformatics , biochemistry , genetics
Abstract In cancerous cells, significant changes occur in the activity of signaling pathways affecting a wide range of cellular activities ranging from growth and proliferation to apoptosis, invasiveness, and metastasis. Extensive changes also happen with respect to the metabolism of a cancerous cell encompassing a wide range of functions that include: nutrient acquisition, biosynthesis of macromolecules, and energy generation. These changes are important and some therapeutic approaches for treating cancers have focused on targeting the metabolism of cancerous cells. Oncogenes and tumor suppressor genes have a significant effect on the metabolism of cells. There appears to be a close interaction between metabolism and the signaling pathways in a cancerous cell, in which the interaction provides the metabolic needs of a cancerous cell for uncontrolled proliferation, resistance to apoptosis, and metastasis. In this review, we have reviewed the latest findings in this regard and briefly review the most recent research findings regarding targeting the metabolism of cancer cells as a therapeutic approach for treatment of cancer.