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The emerging role of miR‐128 in musculoskeletal diseases
Author(s) -
Shang Qi,
Shen Gengyang,
Chen Guifeng,
Zhang Zhida,
Yu Xiang,
Zhao Wenhua,
Zhang Peng,
Chen Honglin,
Tang Kai,
Yu Fuyong,
Tang Jingjing,
Liang De,
Jiang Xiaobing,
Ren Hui
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30179
Subject(s) - microrna , mesenchymal stem cell , regeneration (biology) , bone remodeling , bone marrow , microbiology and biotechnology , cancer research , biology , stem cell , apoptosis , bioinformatics , medicine , immunology , genetics , gene
MicroRNA‐128 (miR‐128) is associated with cell proliferation, differentiation, migration, apoptosis, and survival. Genetic analysis studies have demonstrated that miR‐128 participates in bone metabolism, which involves bone marrow–derived mesenchymal stem cells, osteoblasts, osteoclasts, and adipocytes. miR‐128 also participates in regeneration of skeletal muscles by targeting myoblast‐associated proteins. The deregulation of miR‐128 could lead to a series of musculoskeletal diseases. In this review, we discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.