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Zinc finger E‐box binding homeobox 1 and atherosclerosis: New insights and therapeutic potential
Author(s) -
Li Heng,
Zou Jin,
Yu XiaoHua,
Ou Xiang,
Tang ChaoKe
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30177
Subject(s) - homeobox , angiogenesis , zinc finger , transcription factor , biology , pathogenesis , monocyte , microbiology and biotechnology , cancer research , vascular smooth muscle , endothelial stem cell , cell growth , cell , immunology , gene , endocrinology , genetics , smooth muscle , in vitro
Abstract Zinc finger E‐box binding homeobox 1 (ZEB1), an important transcription factor belonging to the ZEB family, plays a crucial role in regulating gene expression required for both normal physiological and pathological processes. Accumulating evidence has shown that ZEB1 participates in the initiation and progression of atherosclerotic cardiovascular disease. Recent studies suggest that ZEB1 protects against atherosclerosis by regulation of endothelial cell angiogenesis, endothelial dysfunction, monocyte‐endothelial cell interaction, macrophage lipid accumulation, macrophage polarization, monocyte‐vascular smooth muscle cell (VSMC) interaction, VSMC proliferation and migration, and T cell proliferation. In this review, we summarize the recent progress of ZEB1 in the pathogenesis of atherosclerosis and provide insights into the prevention and treatment of atherosclerotic cardiovascular disease.