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The potential use of theranostic bacteria in cancer
Author(s) -
Azizian Khalil,
Pustokhina Inna,
Ghanavati Roya,
Hamblin Michael R.,
Amini Abolfazl,
Kouhsari Ebrahim
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30152
Subject(s) - cancer therapy , cancer , medicine , treatment modality , therapeutic modalities , drug , pharmacology , cancer research
Abstract Conventional chemotherapy approaches have not been fully successful in the treatment of cancer, due to limitations imposed by the pathophysiology of solid tumors, leading to nonspecific drug uptake by healthy cells, poor bioavailability, and toxicity. Thus, novel therapeutic modalities for more efficient cancer treatment are urgently required. Living bacteria can be used as a theranostic approach for the simultaneous diagnosis and therapy of tumors. Herein, we summarize the currently available literature focused on the advantages and challenges for the use of theranostic bacteria in cancer therapy.