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Zebrafish hhatla is involved in cardiac hypertrophy
Author(s) -
Shi Xingjuan,
Zhang Yu,
Gong Yijie,
Chen Mengying,
BrandArzamendi Koroboshka,
Liu Xiangdong,
Wen XiaoYan
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30106
Subject(s) - zebrafish , muscle hypertrophy , calcineurin , medicine , heart failure , hypertrophic cardiomyopathy , biology , endoplasmic reticulum , hedgehog signaling pathway , cardiac hypertrophy , microbiology and biotechnology , endocrinology , signal transduction , genetics , gene , transplantation
Cardiac hypertrophy is a compensatory response to pathological stimuli, ultimately progresses to cardiomyopathy, heart failure, or sudden death. Although many signaling pathways have been reported to be involved in the hypertrophic process, it is still not fully clear about the underlying molecular mechanisms for cardiac hypertrophy. Hedgehog acyltransferase‐like (Hhatl), a sarcoplasmic reticulum‐resident protein, exhibits high expression in the heart and muscle. However, the biological role of Hhatl in the heart remains unknown. In this study, we first found that the expression level of Hhatl is markedly decreased in cardiac hypertrophy. We further studied the role of hhatla , homolog of Hhatl with the zebrafish model. The depletion of hhatla in zebrafish leads to cardiac defects, as well as an enhanced level of hypertrophic markers. Besides, we found that calcineurin signaling participates in hhatla depletion‐induced cardiac hypertrophy. Together, these results demonstrate a critical role for hhatla in cardiac hypertrophy.