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The role of NOX4 in pulmonary diseases
Author(s) -
Li ZiMing,
Xu ShengYa,
Feng YiZhuo,
Cheng YuRui,
Xiong JianBing,
Zhou Yong,
Guan ChaXiang
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.30005
Subject(s) - nox4 , nicotinamide adenine dinucleotide phosphate , nadph oxidase , pulmonary fibrosis , acute respiratory distress , respiratory system , biology , lung , microbiology and biotechnology , medicine , chemistry , enzyme , oxidase test , biochemistry
Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a subtype of the NOX family, which is mainly expressed in the pulmonary vasculature and pulmonary endothelial cells in the respiratory system. NOX4 has unique characteristics, and is a constitutively active enzyme that primarily produces hydrogen peroxide. The signaling pathways associated with NOX4 are complicated. Negative and positive feedback play significant roles in regulating NOX4 expression. The role of NOX4 is controversial because NOX4 plays a protective or damaging role in different respiratory diseases. This review summarizes the structure, enzymatic properties, regulation, and signaling pathways of NOX4. This review then introduces the roles of NOX4 in different diseases in the respiratory system, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis.