Premium
microRNA‐related single‐nucleotide polymorphisms and breast cancer
Author(s) -
Bahreini Farbod,
Rayzan Elham,
Rezaei Nima
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29966
Subject(s) - microrna , single nucleotide polymorphism , breast cancer , biology , gene , genetics , rna , cancer , computational biology , bioinformatics , genotype
Breast cancer, as the most common cancer in women which affects patients both mentally and physically, requires great attention in many areas and many levels as this cancer is known to be multifactorial. Single‐stranded molecules called microRNAs with near 22 nucleotides are seen to act in central dogma of molecular biology by inhibiting the translation process; it is demonstrated that any alteration in their sequence especially single‐nucleotide polymorphisms (SNPs) may lead into increasing the breast cancer risk. miR‐SNPs are considered to be the potential biomarkers for early detection of breast cancer. As a result, this review documents the well‐known miR‐SNPs that are known to be associated with breast cancer. In this regard, two principals were discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.