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Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
Author(s) -
Ruberti Olívia Moraes,
Sousa Andressa Silva,
Viana Laís Rosa,
Pereira Gomes Moisés Felipe,
Medeiros Alessandra,
Gomes Marcondes Maria Cristina Cintra,
Borges Luciano de Figueiredo,
Crestani Carlos Cesar,
Mostarda Cristiano,
Moraes Telma Fátima da Cunha,
Canevarolo Rafael Renatino,
Delbin Maria Andreia,
Rodrigues Bruno
Publication year - 2021
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29919
Subject(s) - ovariectomized rat , medicine , endocrinology , myocardial infarction , aerobic exercise , inflammation , proinflammatory cytokine , hormone
This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin‐proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin‐10, and decreased pro‐inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.