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microRNAs involved in T‐cell development, selection, activation, and hemostasis
Author(s) -
Emamgolizadeh Gurt Tapeh Behnam,
Mosayyebi Bashir,
Samei Mahdieh,
Beyrampour Basmenj Hanieh,
Mohammadi Ali,
Alivand Mohammad R.,
Hassanpour Parviz,
Solali Saeed
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29689
Subject(s) - microrna , immune system , biology , regulation of gene expression , function (biology) , gene , t cell , disease , gene expression , negative selection , microbiology and biotechnology , computational biology , immunology , genetics , genome , medicine , pathology
MicroRNAs (miRNAs) characterized by small, noncoding RNAs have a fundamental role in the regulation of gene expression at the post‐transcriptional level. Additionally, miRNAs have recently been identified as potential regulators of various genes involved in the pathogenesis of the autoimmune and inflammatory disease. So far, the interaction between miRNAs and T lymphocytes in the immune response as a new and significant topic has not been emphasized substantially. The role of miRNAs in different biological processes including apoptosis, immune checkpoints and the activation of immune cells is still unclear. Aberrant miRNA expression profile affects various aspects of T‐cell function. Accordingly, in this literature review, we summarized the role of significant miRNAs in T‐cell development processes. Consequently, we demonstrated precise mechanisms that candidate miRNAs interfere in Immune response mediated by different types of T cells. We believe that a good understanding of the interaction between miRNAs and immune response contributes to the new therapeutic strategies in relation to disease with an immunological origin.