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Adipose‐derived stem cells: An appropriate selection for osteogenic differentiation
Author(s) -
Shafaei Hajar,
Kalarestaghi Hossein
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29681
Subject(s) - mesenchymal stem cell , microbiology and biotechnology , adipose tissue , stem cell , cellular differentiation , regeneration (biology) , adipogenesis , tissue engineering , biology , chemistry , biochemistry , genetics , gene
Mesenchymal stem cells (MSCs) are a major component of various forms of tissue engineering. MSCs have self‐renewal and multidifferential potential. Osteogenic differentiation of MSCs is an area of attention in bone regeneration. One form of MSCs are adipose‐derived stem cells (ASCs), which can be simply harvested and differentiated into several cell lineages, such as chondrocytes, adipocytes, or osteoblasts. Due to special properties, ASCs are frequently used in vitro and in vivo bone regeneration. Identifying factors involved in osteogenic differentiation of ASCs is important for better understanding the mechanism of osteogenic differentiation. Different methods are used to stimulate osteogenesis of ASCs in literature, including common osteogenic media, growth factors, hormones, hypoxia, mechanical and chemical stimuli, genetic modification, and nanotechnology. This review article provides an overview describing the isolation procedure, characterization, properties, current methods for osteogenic differentiation of ASCs, and their basic biological mechanism.