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Proteomics reveals different pathological processes of adipose tissue, liver, and skeletal muscle under insulin resistance
Author(s) -
Li Yaqi,
Ma Quantao,
Li Pengfei,
Wang Jingkang,
Wang Min,
Fan Yuanyuan,
Wang Tieshan,
Wang Chunguo,
Wang Ting,
Zhao Baosheng
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29658
Subject(s) - pathological , adipose tissue , proteomics , insulin resistance , skeletal muscle , biology , mechanism (biology) , bioinformatics , computational biology , liver tissue , insulin , pathology , medicine , endocrinology , biochemistry , gene , philosophy , epistemology
Type 2 diabetes mellitus is the most common type of diabetes, and insulin resistance (IR) is its core pathological mechanism. Proteomics is an ingenious and promising Omics technology that can comprehensively describe the global protein expression profiling of body or specific tissue, and is widely applied to the study of molecular mechanisms of diseases. In this paper, we focused on insulin target organs: adipose tissue, liver, and skeletal muscle, and analyzed the different pathological processes of IR in these three tissues based on proteomics research. By literature studies, we proposed that the main pathological processes of IR among target organs were diverse, which showed unique characteristics and focuses. We further summarized the differential proteins in target organs which were verified to be related to IR, and discussed the proteins that may play key roles in the emphasized pathological processes, aiming at discovering potentially specific differential proteins of IR, and providing new ideas for pathological mechanism research of IR.