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Circulating and tissue microRNAs as a potential diagnostic biomarker in patients with thrombotic events
Author(s) -
JafarzadehEsfehani Reza,
Mostafa Parizadeh Seyed,
Sabeti Aghabozorgi Amirsaeed,
Yavari Negar,
SadrNabavi Ariane,
Alireza Parizadeh Seyed,
Ghandehari Maryam,
Javanbakht Afsane,
RezaeiKalat Afsaneh,
Mahdi Hassanian Seyed,
Vojdanparast Mohammad,
Ferns Gordon A.,
Khazaei Majid,
Avan Amir
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29639
Subject(s) - thrombosis , microrna , biomarker , medicine , venous thrombosis , disease , bioinformatics , diagnostic biomarker , pathology , radiology , diagnostic accuracy , biology , gene , biochemistry
Venous and arterial thrombosis are conditions that have a considerable burden if left untreated. The hypoxia‐induced by the occluded vessel can disrupt the circulation of any organ, the cornerstone of treating thrombosis is rapid diagnosis and appropriate treatment. Diagnosis of thrombosis may be made by using laboratory tests or imaging techniques in individuals who have clinical manifestations of a thrombotic event. The use of serum micro ribonucleic acids (RNAs) has recently been applied to the diagnosis of thrombosis. These small RNA molecules are emerging as new diagnostic markers but have had very limited applications in vascular disease. Most of the articles provided various microRNAs with different levels of accuracy. However, there remains a lack of an appropriate panel of the most specific microRNA in the literature. The purpose of the present review was to summarize the existing data on the use of microRNAs as a diagnostic biomarker for venous thrombosis.