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A glimpse into molecular mechanisms of embryonic stem cells pluripotency: Current status and future perspective
Author(s) -
Fathi Maroufi Nazila,
Hasegawa Kouichi,
Vahedian Vahid,
Nazari Soltan Ahmad Saeed,
Zarebkohan Amir,
Miresmaeili Mazrakhondi Seyed Ali,
Hosseini Vahid,
Rahbarghazi Reza
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29616
Subject(s) - embryonic stem cell , stem cell , biology , microbiology and biotechnology , adult stem cell , cellular differentiation , regenerative medicine , genetics , gene
Embryonic stem cells have potential differentiation ability into a large variety of cell lineages and proved to be an effective therapeutic modality. However, prolonged in vitro and ex‐vivo expansions impair embryonic stem cells multipotentiality, and thereby limit their clinical application. In the past few years, research collected attempts to explore new insights into the molecular mechanisms participate in the stemness capacity of embryonic stem cells. Along with these comments, modalities and strategies with the potential to maintain embryonic stem cells multipotentiality are of great interest. In this review, the authors attempted to discuss the pathways participating in the preservation of embryonic stem cells multipotentiality and emphasized the novel strategies that help to harness regenerative potential.