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Circular RNA; a new biomarker for breast cancer: A systematic review
Author(s) -
Jahani Shima,
Nazeri Elahe,
MajidzadehA Keivan,
Jahani Mona,
Esmaeili Rezvan
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29558
Subject(s) - circular rna , biomarker , microrna , breast cancer , metastasis , biology , cancer , colorectal cancer , cancer research , bioinformatics , computational biology , medicine , gene , genetics
Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell‐type and stage‐specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.