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lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR‐1301‐3p/INCENP axis and interacting with SOX2
Author(s) -
Zhang Chunyan,
Xie Linsen,
Fu Yin,
Yang Juanjuan,
Cui Yuanbo
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29448
Subject(s) - competing endogenous rna , downregulation and upregulation , cancer research , cell growth , biology , sox2 , cell cycle , cell , long non coding rna , cell migration , microbiology and biotechnology , transcription factor , gene , genetics
Long noncoding RNAs (lncRNAs) have been reported to participate in the development of multiple cancers, including esophageal squamous cell carcinoma (ESCC). A growing number of studies have demonstrated that lncRNA myocardial infarction‐associated transcript (MIAT) played an oncogenic role in several human malignancies, but its expression and function in ESCC remain unknown. In this study, we found that MIAT was significantly increased in ESCC tissues, as well as cell lines. Downregulation of MIAT suppressed ESCC cell proliferation, cell cycle, migration, and invasion. Mechanical studies revealed that MIAT promoted ESCC cell proliferation and cell cycle by acting as a competitively endogenous RNA (ceRNA) to upregulate the inner centromere protein (INCENP) expression through sponging miR‐1301‐3p. Furthermore, we uncovered that MIAT‐SOX2 formed a positive feedback loop to facilitate cell proliferation, migration, and invasion of ESCC. Our findings indicated that MIAT promoted ESCC progression via targeting INCENP/miR‐1301‐3p axis and interacting with SOX2, suggesting novel potential therapeutic targets for ESCC.

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