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Adherent‐invasive Escherichia coli (AIEC): Cause or consequence of inflammation, dysbiosis, and rupture of cellular joints in patients with IBD?
Author(s) -
Perna Angelica,
Hay Eleonora,
Contieri Marcella,
De Luca Antonio,
Guerra Germano,
Lucariello Angela
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29430
Subject(s) - escherichia coli , dysbiosis , bacteroides fragilis , fusobacterium nucleatum , microbiology and biotechnology , biology , disease , inflammation , bacteria , immunology , medicine , gut flora , pathology , genetics , gene , antibiotics , porphyromonas gingivalis
There are many factors contributing to the development of gastrointestinal diseases, grouped into genetic, environmental, and lifestyle factors. In recent years attention has fallen on pathogens; in particular, Bacteroides fragilis , Fusobacterium nucleatum , Escherichia coli ( E. coli ) and Helicobacter pylori have been studied. Several points remain to be clarified, and above all, as regards the adherent‐invasive E. coli strains of E. coli , one wonders if they are a cause or a consequence of the disease. In this review, we have tried to clarify some points by examining a series of recent publications regarding the involvement of the bacterium in the pathology, even if other studies are necessary.