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MicroRNAs in breast cancer: Roles, functions, and mechanism of actions
Author(s) -
Abolghasemi Maryam,
Tehrani Sadra Samavarchi,
Yousefi Tooba,
Karimian Ansar,
Mahmoodpoor Ata,
Ghamari Aliakbar,
JadidiNiaragh Farhad,
Yousefi Mehdi,
Kafil Hossein Samadi,
Bastami Milad,
Edalati Mahdi,
Eyvazi Shirin,
Naghizadeh Mohsen,
Targhazeh Niloufar,
Yousefi Bahman,
Safa Amin,
Majidinia Maryam,
Rameshknia Vahid
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29396
Subject(s) - wnt signaling pathway , microrna , carcinogenesis , breast cancer , signal transduction , biology , mechanism (biology) , cancer , cancer research , protein kinase b , kinase , pi3k/akt/mtor pathway , protein kinase a , bioinformatics , microbiology and biotechnology , gene , genetics , philosophy , epistemology
Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.