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Progenitor‐cell‐enriched micrografts as a novel option for the management of androgenetic alopecia
Author(s) -
Ruiz Rafael G.,
Rosell Jose M. C.,
Ceccarelli Gabriele,
De Sio Ciro,
De Angelis Gabriella C.,
Pinto Hernan,
Astarita Carlo,
Graziano Antonio
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29335
Subject(s) - scalp , regeneration (biology) , dermis , regenerative medicine , hair transplantation , hair follicle , medicine , hair growth , hair loss , progenitor cell , stem cell , surgery , biology , dermatology , pathology , physiology , microbiology and biotechnology
Regenerative medicine is a multidisciplinary field that combines engineering and life science principles to promote regeneration, potentially restoring the physiological condition in diseased tissues. Specifically, the developments of complex grafts enhance the intrinsic regenerative capacity of the host by altering its environment. Autologous micrografts obtained through Rigenera® micrografting technology are able to promote derma and bone regeneration. Androgenetic alopecia (AGA) leads to a progressive thinning of scalp hair affecting 60–70% of the adult population worldwide. Pharmacological treatment offers moderate results and hair transplantation represents the only permanent treatment option. The aim of this study was to demonstrate the role of dermis micrografting in the treatment of AGA by clinical and histological evaluations after 4, 6, and 12 months. Hair growth and density were improved at all indicated times. Those outcomes were also confirmed by the TrichoScan® analysis, reporting an increase of total hair count and density with an increase and reduction of anagen and telogen phases, respectively. Scalp dermoscopic analysis showed an improvement of hair density and histological analysis indicated a clear amelioration of the scalp, development of hair follicles, and a beginning of cuticle formation. Collectively, those results suggest a possible use of the micrografts as a novel therapeutic option in the management of AGA.