Premium
Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma
Author(s) -
Rahmani Farzad,
Ziaeemehr Aghigh,
Shahidsales Soodabeh,
Gharib Masoumeh,
Khazaei Majid,
Ferns Gordon A.,
Ryzhikov Mikhail,
Avan Amir,
Hassanian Seyed M.
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29333
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , microrna , cancer research , hepatocellular carcinoma , biology , signal transduction , phosphoinositide 3 kinase , rptor , pathogenesis , kinase , microbiology and biotechnology , immunology , gene , genetics
Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.