Premium
Developments in the study of gastrointestinal microbiome disorders affected by FGF19 in the occurrence and development of colorectal neoplasms
Author(s) -
Peng Meichang,
Zheng Qiaowen,
Liu Peiqi,
Liang Xinyun,
Zhang Min,
Wang Yan,
Zhao Yi
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29322
Subject(s) - fgf19 , colorectal cancer , microbiome , insulin resistance , hormone , inflammation , biology , mouse model of colorectal and intestinal cancer , medicine , cancer research , cancer , gastroenterology , fibroblast growth factor , bioinformatics , insulin , receptor
Colorectal neoplasms are a type of malignant digestive system tumor that has become the third‐highest morbidity tumor in China and the fourth leading cause of cancer‐related death worldwide. The role of the gastrointestinal (GI) microbiome in bile acid metabolism, inflammation, and insulin resistance and its strong correlation with the occurrence and development of colorectal neoplasms have gradually led to it becoming a target area of tumor research. Fibroblast growth factor (FGF) 19 is a hormone that is secreted in mainly the ileum and can regulate bile acid biosynthesis, improve inflammation, and regulate insulin resistance. The relationship of the GI microbiome, FGF19 and its carcinogenic activities in colorectal neoplasms enticed us to search for potential targets and research ideas for the clinical diagnosis and treatment of colorectal neoplasms.