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c‐Myc controls the fate of neural progenitor cells during cerebral cortex development
Author(s) -
Wang XiuLi,
Ma YanXia,
Xu RenJie,
Ma JinJin,
Zhang HongCheng,
Qi ShiBin,
Xu JinHui,
Qin XuZhen,
Zhang HaoNan,
Liu ChangMei,
Chen JianQuan,
Li Bin,
Yang HuiLin
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29297
Subject(s) - neocortex , electroporation , progenitor cell , cerebral cortex , microbiology and biotechnology , biology , neural stem cell , precursor cell , cortex (anatomy) , regulator , progenitor , neuroscience , stem cell , cell , gene , genetics
The anatomical structure of the mammalian cerebral cortex is the essential foundation for its complex neural activity. This structure is developed by proliferation, differentiation, and migration of neural progenitor cells (NPCs), the fate of which is spatially and temporally regulated by the proper gene. This study was used in utero electroporation and found that the well‐known oncogene c‐Myc mainly promoted NPCs’ proliferation and their transformation into intermediate precursor cells. Furthermore, the obtained results also showed that c‐Myc blocked the differentiation of NPCs to postmitotic neurons, and the expression of telomere reverse transcriptase was controlled by c‐Myc in the neocortex. These findings indicated c‐Myc as a key regulator of the fate of NPCs during the development of the cerebral cortex.