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Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity
Author(s) -
Wan Jie,
Cai Wei,
Wang Huixuan,
Cheng Jianjun,
Su Zhaoliang,
Wang Shengjun,
Xu Huaxi
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29287
Subject(s) - innate lymphoid cell , immunity , immunology , context (archaeology) , biology , cytokine , proinflammatory cytokine , homeostasis , immune system , inflammation , microbiology and biotechnology , paleontology
Type 2 innate lymphoid cells (ILC2s) have multiple functions that can respond to allergic diseases, parasite infection, metabolic homeostasis, tissue repair, and adipose metabolism homeostasis. In these diseases, ILC2s can be activated by various inflammatory cytokines released by damaged cells. Activated ILC2s produce different type 2 cytokines, including interleukin (IL)‐4, IL‐5, IL‐9, and IL‐13, which involved in the pathogenesis of many diseases. In recent years, the relationship between ILC2s and tumor diseases has attracted more and more attention. The role of ILC2s in tumor immunity depends on its surface molecules and cytokine context. This review aims to conclude tumorigenic and antitumorigenic roles of ILC2s, and the characters of ILC2s‐related cytokines in tumor diseases to provide a comprehensive overview of the impact of ILC2s in tumor immunity.