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The circ_0021977/miR‐10b‐5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer
Author(s) -
Lu Chen,
Jiang Wei,
Hui Bingqing,
Rong Dawei,
Fu Kai,
Dong Chaoxi,
Tang Weiwei,
Cao Hongyong
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29135
Subject(s) - colorectal cancer , microrna , transcriptome , cancer research , biology , gene , lymph node metastasis , metastasis , regulator , circular rna , cancer , medicine , gene expression , genetics
An in‐depth understanding of circular RNAs (circRNAs) indicates that they are abundant in the eukaryotic transcriptome. Many circRNAs act as microRNA sponges; thus, they represent a new type of regulatory factor. However, the role of circRNA in colorectal cancer (CRC) remains largely unknown. Low circ_0021977 expression in patients with CRC is associated with higher tug‐lymph node metastasis (TNM) stage and poorer prognosis compared with patients with high circ_0021977 expression. Moreover, miR‐10b‐5p was shown to be a target of circ_0021977, and p21 and p53 are suggested to be putative target genes of miR‐10b‐5p. The results showed that the circ_0021977/miR‐10b‐5p/p21&p53 regulatory axis suppresses proliferation, migration, and invasion by CRC cells. This evidence reveals new relationships and brings new highlights to the treatment of CRC.