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Circular RNA hsa_circRNA_103809 promoted hepatocellular carcinoma development by regulating miR‐377‐3p/FGFR1/ERK axis
Author(s) -
Zhan Wei,
Liao Xin,
Chen Zhongsheng,
Li Lianghe,
Tian Tian,
Yu Lei,
Wang Wei,
Hu Qiyan
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29092
Subject(s) - gene knockdown , fibroblast growth factor receptor 1 , circular rna , hepatocellular carcinoma , cancer research , small hairpin rna , mapk/erk pathway , microrna , suppressor , rna , biology , chemistry , microbiology and biotechnology , signal transduction , receptor , cancer , fibroblast growth factor , gene , biochemistry , genetics
In the last decade, circular RNAs (circRNAs) emerge as important regulators in multiple biological processes. Lately, it is reported hsa_circRNA_103809 could play vital parts in several types of cancers. Based on the analysis of GEO data (GSE97332), hsa_circRNA_103809 was found to be dysregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying regulatory mechanisms of hsa_circRNA_103809 in HCC remain unclear. Our results suggested that hsa_circRNA_103809 was overexpressed in HCC patients, and hsa_circRNA_103809 knockdown remarkably inhibited the proliferation, cycle progression, and migration of HCC cells. The investigations of molecular showed that hsa_circRNA_103809 could elevate the protein expression of a miR‐377‐3p target, fibroblast growth factor receptor 1 (FGFR1), through interacting with miR‐377‐3p and decreasing its expression level. Additionally, in vivo assays revealed hsa_circRNA_103809 short hairpin RNA served as a tumor suppressor through downregulating FGFR1 in HCC. This study systematically investigated novel regulatory signaling of hsa_circRNA_103809/miR‐377‐3p/FGFR1 axis, providing insights into hepatocellular carcinoma treatment from bench to clinic.