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Regulatory mechanisms of microRNAs in colorectal cancer and colorectal cancer stem cells
Author(s) -
Shirmohamadi Masoud,
Eghbali Elham,
Najjary Shiva,
Mokhtarzadeh Ahad,
Kojabad Amir Baghbanzadeh,
Hajiasgharzadeh Khalil,
Lotfinezhad Parisa,
Baradaran Behzad
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.29042
Subject(s) - microrna , carcinogenesis , cancer stem cell , colorectal cancer , biology , cancer research , stem cell , metastasis , cancer , angiogenesis , untranslated region , somatic cell , gene , messenger rna , genetics
Colorectal cancer (CRC) is one of the most lethal and hard‐to‐treat cancers in the world, which in its advanced stages, surgery and chemotherapy are the main common treatment approaches. The microRNAs (miRNAs), as novel markers for CRC detection, promote their regulatory effects via the 3′‐untranslated binding region (3′‐UTR) of target messenger RNA in posttranscriptional regulation of genes and also play a pivotal role in modulating resistance to chemotherapeutic agents. These small noncoding RNAs have also a critical role in CRC stem cells (CRCSCs) regulation, comprising self‐renewal, differentiation, and tumorigenesis. Cancer stem cells (CSCs) are distinctive cell types inside a tumor tissue that are believed to derive from normal somatic stem cells. The CSCs have self‐renewal abilities, angiogenesis, as well as specific surface markers expression characteristics. Furthermore, they are frequently criticized for tumor maintenance, treatment resistance, tumor development, and distant metastasis. In this review, we discuss the current understandings of CRCSCs and their environment with a focus on the role of miRNAs on the regulation of CSCs and their targeting application in CRC treatment.