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Potential drugs used in the antibody–drug conjugate (ADC) architecture for cancer therapy
Author(s) -
Yaghoubi Sajad,
Karimi Mohammad Hossein,
Lotfinia Majid,
Gharibi Tohid,
MahiBirjand Motahare,
Kavi Esmaeil,
Hosseini Fahimeh,
Sineh Sepehr Koushan,
Khatami Mehrdad,
Bagheri Nader,
AbdollahpourAlitappeh Meghdad
Publication year - 2020
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28967
Subject(s) - antibody drug conjugate , drug , cytotoxic t cell , conjugate , internalization , small molecule , pharmacology , cancer , medicine , cancer research , chemistry , antibody , monoclonal antibody , cell , in vitro , immunology , biochemistry , mathematical analysis , mathematics
Cytotoxic small‐molecule drugs have a major influence on the fate of antibody–drug conjugates (ADCs). An ideal cytotoxic agent should be highly potent, remain stable while linked to ADCs, kill the targeted tumor cell upon internalization and release from the ADCs, and maintain its activity in multidrug‐resistant tumor cells. Lessons learned from successful and failed experiences in ADC development resulted in remarkable progress in the discovery and development of novel highly potent small molecules. A better understanding of such small‐molecule drugs is important for development of effective ADCs. The present review discusses requirements making a payload appropriate for antitumor ADCs and focuses on the main characteristics of commonly‐used cytotoxic payloads that showed acceptable results in clinical trials. In addition, the present study represents emerging trends and recent advances of payloads used in ADCs currently under clinical trials.