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LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR‐377‐3p
Author(s) -
Shi Chengmin,
Liu Tonglei,
Chi Junlin,
Luo Huayou,
Wu Zhizhong,
Xiong Binghong,
Liu Shuang,
Zeng Yujian
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28934
Subject(s) - gene knockdown , flow cytometry , apoptosis , downregulation and upregulation , cancer research , cell growth , cancer , tumor progression , in vivo , chemistry , cell , biology , microbiology and biotechnology , gene , biochemistry , genetics
Up to date, the mechanism of gastric cancer (GC) development is poorly understood. This study was to demonstrate the effects of LINC00339 on GC progression. Here, we found that LINC00339 was overexpressed expressed in GC tissues and predicted poor outcome. By CCK8, colony formation and Transwell assays, we showed LINC00339 knockdown suppressed GC cell proliferation, migration, and invasion in vitro. Flow cytometry analysis (FACS) indicated that LINC00339 knockdown induced tumor cell apoptosis. Besides, we utilized the xenograft assay and found that LINC00339 depletion led to decreased tumor growth in vivo. Mechanistically, miR‐377‐3p was found to be inhibited by LINC00339. And LINC00339 suppressed miR‐377‐3p to upregulate DCP1A, which consequently promoted GC progression. In conclusion, LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR‐377‐3p.